Molecular Heterogeneity and Evolution in Breast Cancer

Breast cancer comprises a heterogeneous group of tumor subtypes, whether defined by immunohistochemistry key proteins, RNA expression profiles, or genetic alterations, and each these subtypes may benefit from distinct treatment approach. However, there can be striking heterogeneity within tumors, which pose challenges to the development personalized approaches therapy. Intratumor divided into three main categories: genetic, phenotypic, microenvironmental. Here, we review technologies interrogate categories in patient samples, as well current state understanding breast cancer, cell cell, across different regions same mass, treatment, metastasis. Efforts characterize longitudinally will crucial oncology for cancer.